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KMID : 0390320100200020149
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Chungbuk Medical Journal
2010 Volume.20 No. 2 p.149 ~ p.155
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Changes in Sex Hormones in Patients with Breast Cancer Who Received Adjuvant Chemotherapy
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Lee Ki-Hyeong
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Abstract
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Purpose: To determine menopausal status in patients with breast cancer is clinically critical for the adjuvant hormonal therapy. Many patients who are undergoing chemotherapy experience amenorrhea, but amenorrhea alone is not sufficient for determination of menopause. Current cancer treatment guidelines recommend serial FSH and estradiol tests to determine menopause in these patients, but there is no consensus on how frequently and how many time of these test should be done. In this study we evaluated the changes in these hormone levels in patients with breast cancer undergone adjuvant chemotherapy.
Materials and Methods : We retrospectively analyzed changes in the pre- and post-chemotherapy FSH and estradiol levels in patients who had undergone surgery of breast cancer in Chungbuk National University Hospital. Patients who had received adjuvant chemotherapy containing anthracyclines were included when pre-chemotherapy levels of FSH and estradiol are available.
Results: From October 2007 to October 2010, 78 patients with breast cancer were included in this study. Compared to pre-chemotherapy baselines, FSH level rose from 0.3 ? 79.5 pg/mL (15.8 ± 20.0, mean ± SD) to 2.5 ? 111.0 pg/mL (44.7 ± 21.1) (p<0.0001), and estradiol level decreased from 6.3 ? 570.0 pg/mL (170.7 ± 164.9) to 2.0 ? 108.0 pg/mL (40.9 ± 29.2) (p<0.0001). The changes in estradiol level tended to sustain longer than that of FSH posttherapy.
Conclusion: In patients with chemotherapy induced amenorrhea, at least 2 or 3 times of measurement of FSH and estradiol level post-chemotherapy is needed to determine the menopausal status.
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KEYWORD
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Chemotherapy, Amenorrhea, FSH, Estradiol
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